【摘要】 目的观察纤溶酶与盐酸丁咯地尔联合治疗椎-基底动脉供血不足的临床疗效。方法治疗组50例应用纤溶酶200U,每天1次,连续用10天;同时应用盐酸丁咯地尔100mg,每天1次,连续应用15天。对照组48例应用盐酸丁咯地尔100mg,每天1次,连续15天。观察治疗前后血液流变学指标变化并评价其疗效。结果治疗组总有效率90.0%,对照组总有效率62.5%,两组差异显著(P<0.01)。治疗组在改善全血粘度、血浆粘度、增加红细胞变形指数、降低纤维蛋白原方面优于对照组(P<0.05);治疗组患者的凝血酶原时间延长(P<0.05),但不影响出凝血时间(P>0.05)。结论纤溶酶与丁咯地尔联合应用比单纯应用丁咯地尔治疗椎-基底动脉供血不足的疗效显著。更多还原

【Abstract】 Objective To study the effects of defibrase combine wtit Buflomedil Hydrochloride in treating vertebro basilar artery ischemic. Methods 98 patients were divided into treatment and control.One group to treatment with 200 unit defibrase intravenous dripping was applied in NS for 10 days,at same time with Buflomedil Hydrochloride 100mg was applied NS for 15 days,the other group with Buflomedil Hydrochloride 100mg was applied at NS for 15 days.The effects of treatment and hemorheology index were evaluated before and 15days. Results The utility rate of treatment group and control group were respectively 90.0% and 62.5%(P<0.01),and there were significant difference in hemorheology index between the two groups(P<0.05) The treatment group increased plasma prothrombin time(P<0.05) while with no statistic significance on bleeding time and coagulation time(P>0.05). Conclusion Defibrase combine with Buflomedil Hydrochloride is superior to Buflomedil Hydrochloride alone in treating vertebro basilar artery ischemic.更多还原