【摘要】 目的　评价膀胱癌抗原(UBC)对膀胱移行细胞癌(BTCC)的诊断价值。方法　采用ELISA法对89例BTCC及10 8例泌尿系非移行细胞癌(TCC)患者的尿UBC进行检测,并同时行尿脱落细胞学检查。结果　BTCC患者尿UBC均值为30 .5 μg/L ,与泌尿系非TCC患者8.2 μg/L的均值比较,差别有显著性意义(P <0 .0 1)。尿UBC(以8.4 μg/L为最适临界值)和尿细胞学诊断BTCC的敏感性分别为75 .3%和16 .9% ,特异性分别为77.8%和10 0 % ,两者差别均有显著性意义(P <0 .0 1)。结论　尿UBC检测对BTCC的诊断是一种较为敏感、特异且无创的方法,敏感性明显优于尿细胞学,但临床上不能完全替代尿细胞学检查。更多还原

【Abstract】 Objective To determine the c linical efficacy of urinary bladder cancer antigen (UBC) as a novel urine marker for transitional cell carcinoma (TCC) of the bladder. Methods UBC test were carried out for the voided urine samples from 89 cases of TC C and 108 cases of nonurothelial cancer diseases of urinary tract by an enzyme-l inked immunosorbent assay (ELISA), and conventional voided urine cytology (VUC) were carried out for each patient simultaneously. Results The UBC values for the TCC patients (mean 30.5μg/L) were significantly hi gher than the patients without TCC (mean 8.2μg/L)(P< 0.01). At a threshold value of 8.4μg/L, the sensitivity and sepcificity of UBC for detection of TCC were 75.3% and 77.8%, which had significant difference with the corresponding figures of 16.9% and 100% for UCV ( P< 0.01). Conclusion UBC is more sen sitive than VUC in the detection of TCC, but it should not be used as a substitu de for VUC because the latter has a highest specificity of 100%.更多还原