【摘要】 目的　进一步探讨急性时相反应蛋白(APP)在类风湿性关节炎(RA)中的临床意义。　方法　应用Array特种蛋白测定系统测定RA患者及正常组血清类风湿因子(RF)、C -反应蛋白(CRP)、a1-酸性糖蛋白(AAG)、结合珠蛋白(HPT)、铜蓝蛋白(CER )的含量。　结果　RA患者血清RF、CRP、AAG、HPT、CER水平明显高于正常对照组(P <0 .0 0 1)。与RA稳定组相比RA活动组CRP、AAG、HPT、CER明显升高(P <0 .0 0 1)。AAG含量与CRP、HPT、CER含量均呈正的直线相关关系。　结论　APP不仅能反映RA患者的临床状态和炎症程度,还是一种临床用药参考指标更多还原

【Abstract】 Objective To explore the relation between acute-phase protein(APP)and RA. Methods Using Array special protein analysis system,the serum levels of acute-phase proteins ,including Rheumatoid Factor(RF),C-Reactive Protein(CRP), а 1-acidglycoprotein (AAG), Haptoglobin (HPT), and Creruloplasmin (CER) were measured in 20 patients with clinical active RA patients, inactive stage RA patients and 20 normal subjects as control. Results Serum level of RF, CRP, AAG, HPT and CER in active RA patients were increased as compared with the normal subjects and also the inactive RA patients with highly significant difference (P<0.001). AAG serum levels showed close correlation with the levels of CRP (r=0.825), HPT (r=0.898) and CER (r=0.961). Conclusion It is not only useful in evaluation of severity of inflammation in RA patients, but also an indicator of therapeutic response when the 5 APPs are measured simultaneously.更多还原