【摘要】 目的　观察氨基胍、维生素C对糖尿病大鼠免疫功能影响。　方法　利用链脲佐菌素腹腔注射法诱导建立Ⅰ型糖尿病大鼠模型 ,将实验用SD大鼠随机分为正常对照组、糖尿病组、维生素C治疗组、氨基胍治疗组、维生素C和氨基胍联合治疗组。治疗 4周 ,观察治疗期间及治疗后大鼠的一般状况 ,检测血中IgG、IgM含量及外周血粒细胞数量的变化。　结果　①实验性糖尿病大鼠与正常组比较大鼠感染率增加 ;②氨基胍、维生素C均能不同程度的降低糖尿病大鼠的感染率 ;③两种药物均能不同程度的提高糖尿病大鼠IgG、IgM含量及外周血白细胞数量 ,两药联合使用有协同作用。　结论　氨基胍和维生素C能降低糖尿病大鼠感染率 ,提高免疫功能。更多还原

【Abstract】 Objective To observe the effect of Aminoguanidine and Vitamin C on immune function of Streptozotocin-induced Diabetic Rats. Methods Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were allocated to normal control group, model group, Vitamin C group, Aminoguanidine group, Vitamin C and Aminoguanidine group. All rats were treated with corresponding drugs for 4 weeks. During and after the treatment, the general state, blood gloucose levels, immunoglobulin G, immunoglobulin M, and peripheral blood leucocyte in different groups were tested. Results ① Infection rate in all the four model groups increased. ② Aminoguanidine and Vitamin C have no effect on blood gloucose le- vels, while they could improve the general state, increase immunoglobulin G, immunoglobulin M, and peripheral blood leucocyte. ③ Combined two drugs have a cooperated action. Conclusion Aminoguanidine and Vitamin C have no effect in decreasing the blood sugar level but can improve immune function.更多还原