【摘要】 目的　探讨新型抗胆碱药盐酸戊乙奎醚对氨基甲酸类农药中毒的救治效果。　方法　 3 45例氨基甲酸酯类中毒患者入院后随机分为治疗组 (盐酸戊乙奎醚 ,180例 )和对照组 (阿托品 ,165例 ) ,两组其他治疗相同。观察治疗后中毒症状消失时间 ,全血胆碱酯酶活力 (CHE) ,用药剂量 ,不良反应及治愈时间。　结果　治疗组中毒患者中毒症状消失时间 ,胆碱酯酶活力恢复时间 ,用药剂量 ,不良反应 ,治愈时间与对照组比较有显著差异 (P <0 .0 1)。　结论　盐酸戊乙奎醚治疗急性氨基甲酸酯类中毒疗效好 ,起效快 ,药物不良反应少。更多还原

【Abstract】 Objective To investigate the therapeutic effect of penequinine hydrochloride in treating carbamates poisoning. Methods 345 patients with carbamates poisoning were randomly divided into treatment group (n=180) and control group(n=165), and they were treated by penequinine hydrochloride and atropine respectively. The time of poisoning symptoms vanished, and CHE resumed, dosage of medicine, adverse reactions and the time of cure were observed and compared. Results The time of poisoning symptoms vanished, CHE resumed and cure was significantly shorter than that in control group(P<0.01). Dosage of medicine between the two groups showed significant difference(P<0.05).The adverse reaction in treatment group was smaller than that in control group. Conclusion Penequinine hydrochloride has definite clinical effect in treating carbamates poisoning with rapid onset of action and few adverse reaction.更多还原