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糖尿病视网膜病变患者体液免疫状态研究

The Research of Humoral Immunolfunction in Patients with Diabetic Retinopathy

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【作者】 蔡应木杨建鑫焦晓阳林静华黄源春吴映娥徐珊琪

【Author】 CAI Ying-mu,YANG Jian-xin, JIAO Xiao-yang,et al (The First Affiliated Hospital of Shantou University Medical College,Shantou,Guangdong 515041,China)

【机构】 汕头大学医学院第一附属医院汕头大学医学院第一附属医院 广东汕头515041广东汕头515041广东汕头515041

【摘要】 目的:探讨糖尿病视网膜病与机体体液免疫状态的关系。方法:应用日立7170A对30例正常对照组,30例单纯糖尿病(DM)组及30例糖尿病视网膜病变(DR)组的CIC、BF、C3、C4、IgG、IgA、IgM进行检测及分组比较。结果:DM组及DR组的BF、IgG、IgA均显著高于正常对照组(P<0.01);而IgM则显著低于正常对照组(P<0.01)。DR组CIC、C3、C4即显著高于DM组也显著高于正常对照组(P<0.01)。结论:DR、DM均存在体液功能紊乱但DR更甚,体液免疫功能紊乱可能成为DR毛细血管病变的原因之一。

【Abstract】 Objective To explore the relationship of the diabetic retinopathy and the humoral immunol function.Method The level of CIC,BF,C3,C4,IgG,IgA,IgM have been measured with hitachi 7170 A analyzer in 30 normal control (control group),30 diabetes(DM group) and 30 diabeticretinopathypatients.Results The level of BF,IgG, IgA were significantly higher in both DM and DR groups than those in control group(P<0.01),on the contrary,the level of IgM in DM and DR were significantly lower than those in control group(P<0.01).The level of CIC,C3,C4 were significantly higher in DR group than those in DM and control group(P<0.01).Conclusion There were chaotic humoral immunol function in DR DM groups but more seriousness in DR group,and maybe the one of reason that induce the capillary change in DR.

【基金】 广东省卫生厅科研基金项目(编号003490)
  • 【文献出处】 实用医技杂志 ,Journal of Practical Medical Techniques , 编辑部邮箱 ,2005年15期
  • 【分类号】R587.2
  • 【下载频次】63
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