【摘要】 目的测定月桂酰吲达帕胺的电离常数(pKa)及分配系数。方法采用酸碱滴定法测定各不同体积比的丙酮-水溶液中药物半中和点时的pH值作为药物在该体积比的丙酮-水溶液中的pKa值,再外推至纯水中药物浓度无限稀释时的pKa值;采用HPLC配合摇瓶法测定药物的分配系数。结果月桂酰吲达帕胺的pKa为3.87,lgP值为3.190。结论月桂酰吲达帕胺为弱酸性亲脂性药物。更多还原

【Abstract】 Objective To determine the ionization constant and partition coefficient of lauroyl indapamide.Methods The ionization constant was determined with acid-basie titration in acetone/water solutions with different ratios,the pH at half neutralization point was regarded as pKa,the value to infinite diluted in pure water was explored and the lgP was determined with bottle-shaking method by HPLC.Results The pKa and lgP of lauroyl indapamide were 3.87 and 3.190 respectively.Conclusions Lauroyl indapamide is a weak acid with lipophilic property.更多还原