Objective To study the incidence of extended spectrum beta-lactamases (ESBLs) bacterium in nosocomial infection in this region and analyze the drug resistance of the positive and the negative ESBLs bacterium. Methods K-B method with ceftazidime and cefotaxime was performed to screen and confirm the separated bacterium before the test of drug resistance. Results The detection rate of ESBLs of E.coli and Klebsiella pneumoniae was 32.6%(45/138) and 38.1%(34/89) respectively. The drug-resistance rate of ESBLs-p...