【摘要】 目的探讨联合检测尿N-乙酰-β-D-氨基-葡萄糖苷酶(NAG)及尿β2微球蛋白(β2-MG)在过敏性紫癜(AP)肾损害早期诊断中的意义。方法以双夹心酶免疫法及放射免疫法检测94例AP患儿尿NAG、β2-MG水平。结果94例AP患儿中15例尿NAG异常,12例尿β2微球蛋白异常,5例尿NAG、β2微球蛋白均异常,尿NAG异常阳性率为15.96%(15/94),尿β2微球蛋白异常阳性率为12.78%(12/94);尿NAG及尿β2-MG异常的联合阳性率为28.72%(27/94),以上阳性率间两两比较:尿NAG与尿β2-MG阳性率无差异(X2=0.39P>0.05),而两者联合阳性率高于尿NAG(X2=4.41P<0.05),也高于尿β2-MG(X2=7.28P<0.05)。结论尿NAG及尿β2-MG均可作为早期诊断AP肾损害的尿标志性蛋白;应用两者联合指标,可提高其早期诊断阳性率。更多还原

【Abstract】 Objective To investigate the clinical significance of combined detecting of urine(NAG) and β2 microglobulin(β2 - MG) in early diagnosis of anaphylatoid purpura renal injuries. Methods Urine NAG and β2 - MG were detected by use of radioimmunoassay and ELISA in 94 cases with anaphylatoid purpura. Results Among 94 cases, 15 cases were abnormal in urine NAG, 12 cases were abnormal in β2 - MG, 5 cases were abnormal in both urine NAG and β2 - MG thus the positive ratio of urine NAG was 15.96 % (15 /94), β2 - MG microglobulin 12.78% (12/94), two index together 28.72% (27/94). There was no significant difference between positive ratios of urine NAG and β2- MG(X2 = 0.39 P>0.05) ,but the differences reached statistical significance compared the positive ratios of two index together to urine NAG and β2 - MG (X2 = 4.41,7.28 P< 0.05). Conclusions Urine NAG and β2 -MG can be used as early diagnosis index of anaphylatoid purpura renal injuries. The positive ratio would be improved under condition of combined detecting of two indexes.更多还原