【摘要】 目的探讨抗环瓜氨酸肽(CCP)抗体检测对幼年特发性关节炎(JIA)的诊断价值。方法用酶联免疫吸附试验(ELISA)对22例JIA患儿(男9例,女13例)、30例成人类风湿关节炎(RA)患者血清抗CCP抗体、RF进行检测,了解抗CCP抗体在JIA中的诊断价值。结果JIA患儿22例中2例抗CCP抗体阳性,阳性率为9.1%(2/22),显著低于成人RA组阳性率53.3%(16/30),P<0.01;JIA患儿与健康对照组(无CCP抗体阳性)抗CCP抗体阳性率尤差别,P>0.05。结论抗CCP抗体可在JIA中检测到,但阳性率很低,作为JIA诊断指标具有一定的局限性。更多还原

【Abstract】 Objective To assess the clinical significance of antibodies against cyclic citrullinated peptide(anti - CCP) in a cohort of patients with juvenile idiopathic arthritis (JIA). Methods The anti - CCP was tested by an enzyme linked immunosorbent assay (ELISA) in serum samples from 22 patients with JIA(9 boys, 13 girls), with a mean age of 9.1 years(range 1.1 - 16). As control groups, anti - CCP were also tested in sera of 20 healthy children, and 30 adult patients with rheumatoid arthritis(RA). Results Positive anti - CCP were found in sera of 2 patients with JIA(9.1 %), both with lower titre comparing with those of adult patients with anti - CCP positive. In the control groups, none of healthy children was positive for anti - CCP, but 16/30(53. 3%) adults with RA showed anti - CCP positivity. Conclusion Anti - CCP can be detected in children with JIA, but are less frequently present than in adults with RA, so anti - CCP has limited diagnostic value to JIA.更多还原