【摘要】 目的研究肺炎支原体肺炎(MPP)患儿Th1/Th2免疫应答状况。方法用酶联免疫吸附法(ELISA)测定26例MPP急性期患儿和其中9例恢复期及12例健康儿童的血清IFN-γ、IL-4水平.计算IFN/IL-4比值。结果急性期MPP患儿IFN-γ水平明显高于对照组(P<0.01);IL-4水平低于对照组,但无显著差异(P>0.05);IFN-γ/IL-4比值明显高于对照组(P<0.01)。恢复期患儿IFN-γ、IL-4、IFN-γ/IL-4比值均高于急性期患儿.但无显著差异(P均>0.05)。结论MPP患儿存在Th1细胞免疫应答增强.Th2细胞免疫应答减弱,且恢复期持续存在。更多还原

【Abstract】 Objective To study the immune responses of Th1 and Th2 subsets of T cells in 26 children with mycoplasma pneumo-niae pneumonia(MPP).Methods ELISA was used to detect the levels of interferon- γ( IFN- γ) and interleukin-4(IL-4) in the serum in 12 healthy children as normal controls and 26 patients of acute stage as acute stage MPP group, 9 of whom in recovery stage were as recovery stage MPP group. Results IFN - γ level in acute stage MPP group was significant higher than that in normal controls (P<0.01);IL-4 level in acute stage MPP group was lower than that in normal controls, but the difference was not significant(P> 0.05); and IFN - 7/IL - 4 ratio was significant higher than that in normal controls( P<0.01). The levels of IFN - γ,IL - 4 and IFN - γ/IL - 4 ratio in recovery stage MPP group were higher than that in acute stage MPP group, but the difference was not statistically significant (P>0.05).Conclusion Thl responses increase and Th2 responses decrease in children with MPP,and this kind of response persists during the recovery stage.更多还原