【摘要】 目的 :探讨TP在口腔鳞癌基质中的表达与临床病理学参数的关系及其与微血管密度的相关性 ,进一步推断其对口腔鳞癌转移及预后的影响。方法 :采用免疫组化方法检测TP和FⅧ RA在 5 2例口腔不同部位 (舌、口底、颊黏膜、牙龈 )鳞癌和 10例正常口腔黏膜标本中的表达。结果 :TP在口腔鳞癌基质中的表达明显高于正常口腔黏膜组织 (P <0 .0 5 )。TP在口腔鳞癌基质中的表达与口腔鳞癌的临床分期、肿瘤大小、浸润深度、淋巴转移有关 (P <0 .0 5 ) ,而与组织分化无关。TP的表达与MVD呈显著正相关 (P <0 .0 1)。结论 :TP可能在口腔鳞癌的发展过程中起重要作用。TP在口腔鳞癌中有促血管形成的作用 ,与MVD的联合检测可以预测口腔鳞癌的预后。更多还原

【Abstract】 Objective:To study the correlation of thymidine phosphory la se(TP) expression with histological parameters and microvessel density(MVD) in t umor stroma of oral squamous cell carcinoma(OSCC).Methods:52 cas es of oral squamous cell carcinoma and 10 cases of normal oral mucosa were immun ohistochemically stained with a SP method by using monoclonal antibody of TP and FⅧ-RA.The correlation of TP expression with the clinical data and MVD in tumo r stroma was analyzed.Results: The expression of TP in oral squa mous cell carcinoma was much higher than that in normal oral mucosa (P<0.05 ).The expression of TP was positively related to clinical grades,dimension,dept h and lymph nodes metastasis(P<0.05).But it was not related to pathologic grades(P>0.05).There was a positive correlation between the TP expression an d MVD(P<0.01).Conclusion:TP may play an important role in progression of oral squamous cell carcinoma.The expression of TP favors angiogen esis of OSCC.更多还原