【摘要】 目的探讨不同治疗方法对扁桃体癌的疗效及预后因素。方法62例扁桃体癌根据1997年国际抗癌联盟分期标准,Ⅰ期3例,Ⅱ期7例,Ⅲ期17例,Ⅳ期35例。根据不同治疗方法,将62例患者分为3个组,外照射+腔内治疗组(15例),单纯外照射治疗组(31例),外照射+化疗组(16例)。结果62例肿瘤患者的3、5、10年总生存率分别为61.3%(38/62),35.5%(22/62),17.0%(9/53)。外照射+腔内治疗组,单纯外照射组及外照射+化疗组肿瘤局部控制率分别为86.7%(13/15),54.8%(17/31),50.0%(8/16),外照射+腔内治疗组肿瘤局部控制率分别与单纯外照射组和外照射+化疗组相比,均有显著性差异;3个组3、5、10年生存率相比较,均无显著性差异。结论腔内治疗作为原发灶推量方法,能提高肿瘤局部控制率,但不能提高患者生存率。更多还原

【Abstract】 Objective To evaluate the therapeutic effect of different radiotherapy and the prognostic factors in patients with tonsillar carcinoma.Methods Clinical data of 62 patients with pathologically documented tonsillar carcinoma were analyzed restrospectively.Based on TNM staging system,there were 3 cases of stage Ⅰ disease,7 stage Ⅱ,17 stage Ⅲ and 35 stage Ⅳ disease.62 patients were divided into three groups to receive either extemal bean therapy plus intracavitary brachytherapy(EBRT+BRT,n=15),or EBRT only(n=31),or EBRT plus chemotherapy(EBRT+chemo,n=16).Results The 3-,5-,10-year overall survival rates were 61.3%(38/62),35.5%(22/62),and 17.0%(9/53),respectively.The local control rates of group EBRT+BRT,EBRTand EBRT+chemo were 86.7%(13/15),54.8%(17/31),and 50%(8/16),respectively.There was a significant difference in local control rate between group EBRT+BRTand EBRT,or between group EBRT+BRT and EBRT+chemo.All these survival rates showed no statistical significance.Conclusion Brachytherapy,when used to increase the dose effect,may enhance the local control rate,but not increase the survival rate.更多还原