【摘要】 目的研究血管内皮生长因子(vascu lar endothelial growth factor,VEGF)和新生血管在不同分期非小细胞肺癌(non-sm all cell lung cancer,NSCLC)中的表达及其相互关系。方法共收集79例原发性NSCLC手术标本和12例尸检正常肺组织,用免疫组织化学法(S-P法)检测,用免疫组化图象分析系统进行结果处理。结果非小细胞肺癌中VEGF和新生血管的表达水平与正常肺组织相比差异具有显著性(P<0.05);Ⅰ期与Ⅱ期及Ⅲ期之间相比,VEGF和新生血管的表达水平差异同样具有显著性,并且随分期越晚表达越强(P<0.05);不同细胞类型之间的差异无显著性(P>0.05)。结论VEGF的表达水平与新生血管的表达成正相关。更多还原

【Abstract】 Objective To evaluate the expression and relation between VEGF and angiogenesis in different stages of non-small cell lung cancer.Methods The expression of VEGF and angiogenesis were detected using immunohistochemical method in 79 lung cancer tissue and 12 normal tissue.The result was analyzed with immunohistochemical image-analysis system.Results VEGF and angiogenesis in NSCLC were significantly higher than that in normal pulmonary tissue.The expression of VEGF and angiogenesis was closely related to P-TNM stages,but there was no difference between adenocarcinoma and squamouscarcinoma.Conclusion A positive correlation was found between VEGF and angiogenesis in NSCLC.更多还原