【摘要】 RNA沉默是一种由21-26nt RNA分子介导的真核生物体内普遍存在的以序列特定性行为 抑制基因表达的保守途径。RNA沉默最显著的特征在于它是一种非细胞自发的过程,即在植物 和小杆线虫(Caenorhabditis elegans)中RNA沉默均能被局部诱导,随后将沉默状态传导至整个生 物体。RNA沉默的系统传导特性表明,RNA沉默途径中存在着可移动的信号分子。就RNA沉默 信号传导的特征和可能的信号分子等做一综述。更多还原

【Abstract】 RNA silencing is a conserved eukaryotic pathway involved in suppression of gene expression via sequence-specific interactions that are mediated by 21-26nt RNA molecules. One of the most intriguing aspects of RNA silencing is that it is non-cell-autonomous, namely, in both plants and Caenorhabditis elegans it can be induced locally and then spread to distant sites throughout the organism. The systemic spread of silencing reflects the existence of a mobile silencing signal as an integral component of the RNA silencing pathway. The conduction nature of systemic silencing in plants and the possible candidates for the mobile silencing signal and so on were discussed.更多还原