【摘要】 研究新合成化合物哌嗪雌酚酮对老年雌性大鼠骨代谢及子宫的影响。 32只 2 2月龄 SD大鼠 ,随机分为4组 :对照组 (生理盐水 0 .1m l/ kg/ d) ,哌嗪雌酚酮高、中、低剂量组 (2、1和 0 .5 mg/ kg/ d) ,皮下注射 30 d。取胫骨上段制成不脱钙骨制片作骨形态计量学测量分析 ,同时取子宫称重。结果表明 ,与对照组比较 ,哌嗪雌酚酮组骨量增加 ,其中中剂量组骨形成呈增加趋势 ,骨吸收显著降低 ,骨量增加最明显 ;子宫重量无明显变化。我们的结果提示 :哌嗪雌酚酮可预防老年大鼠骨质减少 ,中剂量组效果最明显。且未见明显刺激子宫的副作用。更多还原

【Abstract】 The purpose of this study was to determine the effects of piperazinyl estrone, a new estrogen derivative, on bone turnover, bone mass and uterine weight in female aged rats. Thirty-two Sprague-Dawley female rats at the age of 22 months were treated with vehicle or with piperazinyl estrone (P-E) at 0.5, 1 and 2 mg/kg /day, subcutaneous injection for 1 month. At the time of death, the uterine weight was measured and bone histomorphometric analysis of proximal tibial metaphyses (PTM)was performed in undecalcified sections. Compared with control, bone mass was increased in P-E groups.Dynamic data showed that bone resorption were decreased, but bone formation was not declined and bone mass was increased significantly in P-E (1 mg/kg day) group. There was no significant change in uterine weight.The findings of this study show that piperazinyl estrone at dosage of 1mg/kg/d is most efficacious in preventing the bone losses in aged rats and has no side effect on uterus.更多还原