Increased vascular endothelial growth factor (VEGF) biosynthesis in vascular endothelial cells has been reported to play an obligatory role in promoting angiogenesis. Nevertheless, the intracellular signaling mechanisms of hypoxia-induced VEGF release remain largely unknown. Human umbilical vein endothelial cell lines (ECV304) were cultured in normoxic or hypoxic conditions for 12-24 h and harvested for determination of VEGF mRNA expression and phosphorylation of ERKl/2 and p38 mitogen-activated protein kin...
【更新日期】
2005-08-19
【分类号】
R363
【正文快照】
Vascular endothelial growth faetor(VEGF)15 an angio- genic factor Playing a Pivotal role in most stePs of the angiogenic Process,e.g.,Proliferation and而gration of endothelial cells,而erovaseular ttlbe formation and degra- 14 ActaP勿siologica Siniea,Febll
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