【摘要】 目的研究血管内皮生长因子(VEGF)及其受体Flt-1在人垂体腺瘤中的表达,探讨其表达变化、微血管密度(MVD)与侵袭性垂体腺瘤血管生成的关系。方法采用免疫组织化学技术检测52例垂体腺瘤的VEGF及其受体表达水平,同时检测CD34表达,用于测定垂体腺瘤的MVD,比较其在侵袭性和非侵袭性垂体腺瘤中的差异。结果VEGF及其受体和MVD与垂体腺瘤的侵袭性密切相关(P<0.01)。结论VEGF可能通过促进新生血管形成刺激垂体腺瘤生长和侵袭,其作用机制有待进一步研究。更多还原

【Abstract】 Objective To study the expression of vascular endothelial growth factor (VEGF) and its receptor (Flt-1), and to explore the relationship among the expression, microvessel density (MVD) and angiogenesis in invasive pituitary adenomas.Methods Fifty-two surgical samples of pituitary adenomas were stained immunohistochemically with antibodies of VEGF and Flt-1 to investigate their expression, and MVD was assayed by detecting the expression of CD34. A comparison analysis was made to find the difference between invasive pituitary adenomas and non-invasive pituitary adenomas.Results Both VEGF and its receptor, as well as MVD highly correlated with the invasiveness of pituitary adenomas(P<0.01).Conclusion VEGF may play an important role in invasiveness of pituitary by promoting tumor angiogenesis. The mechanism needs to be studied further.更多还原