【摘要】 以质量分数为98%的甲酸为溶剂,丝素和壳聚糖以不同质量分数及比例共混制备纺丝液进行静电纺丝,并用扫描电镜观察其形态结构。结果表明:当丝素和壳聚糖溶液质量比为70/30,两者质量分数分别为13%～17%和3%～5%时,都能获得连续纤维;当丝素和壳聚糖溶液质量分数分别为17%和4%,两者质量比高于50/50时,均能静电纺得连续纤维,纤维直径随壳聚糖含量的增加而减小,质量比低于50/50时,制成的纳米纤维中含有壳聚糖颗粒。采用红外光谱法测定了丝素/壳聚糖纳米纤维的结构,结果表明:壳聚糖与丝素之间有相互作用,经乙醇处理促进了丝素构象转变为β结构。更多还原

【Abstract】 The electrospinning of silk fibroin (SF)/chitosan(CS)with different concentrations and composition ratios was performed with formic acid (98%(wt)) as a spinning solvent and the morphology was observed by SEM.The results indicate that when the composition ratio is 70/30 and the concentra-tion of SF and CS is 13～17%(wt) and 3～5%(wt) respectively,continuous nanofibers can be obtained ; when the concentrations of SF and CS are 17%(wt) and 4%(wt) and the composition ratio is above 50/ 50,blended solution can be electrospun into continuous nanofibers,the diameter gradually decreasing with the addition of CS;when the composition ratio is lower than 50/50,the SF nanofibers containing CS bead are produced.the conformation of SF/CS nanofibers by ATR-IR is also investigated,which shows that there is reciprocity between SF and CS.The conformation of SF is changed into β-sheet after ethanol treatment.更多还原