【摘要】 目的:研究乙型肝炎表面抗原(HBsAg)携带者孕妇及其新生儿应用乙肝免疫球蛋白(HBIG)对阻断乙肝母婴传播的效果。方法:A组66例,于孕28、32、36周分别注射HBIG200U,B组68例仅常规产前检查及监护。新生儿分为Ⅰ、Ⅱ、Ⅲ组,Ⅰ、Ⅱ组新生儿注射乙肝疫苗(HBVac)10μg和HBIG100U,Ⅲ组新生儿只注射HBVac10μg。结果:A组较B组新生儿出生时外周血HBsAg阳性率显著降低,P<0.05。Ⅰ、Ⅲ组婴儿6月龄HBsAb阳性率差异有显著性,P<0.05。结论:对HBsAg携带者孕晚期应用HBIG可以显著降低新生儿外周血HBsAg阳性率;对HBsAg携带者孕晚期应用HBIG,新生儿出生时应用HBIG和HBVac联合免疫,可以显著提高婴儿6月龄HBsAb的阳性率。更多还原

【Abstract】 ] Objective:To st udy the preventive effect of materneofe tal Hepatitis B virus(HBV)transmission a f ter pregnant women carring HBsAg and the ir newborns have been passive immunized Hepatitis B immunoglobulin(HBIG). Methods:Group A(n=66),whic h HBIG 200 U was given monthly in late p regnancy;Group B(n=68),which abtained only common antenatal care.The newborns were also divided into three Groups:Grou p Ⅰ and group Ⅱ obtained both HBIG and HB Vac,and Group Ⅲ abtained HBVac only. Results:The positive rate of H BsAg of newborns (age≤24h) in Group A was significantly lower than tha t in Group B. As the infants were 6 months old,The HBsAb positive rate of infa nts w as signifcantly higher in Group Ⅰthan in Gr oup Ⅲ.Conclusions: The pregnant women carring HBsAg given HBIG mon thly during late pregnancy can effectively reduce the positive rate of HBsAg of newborns; The pregnant women given HBIG mon thly during late pregnancy and offspr ings obtained HBIG and HBVac as well can eff ectively prove the positive rate of HBsAb o f 6 months infants. [更多还原