【摘要】 目的:研究卵巢上皮性肿瘤组织中p73和p53蛋白的表达,探讨它们在卵巢肿瘤发生发展中的作用。方法:应用免疫组化SP法检测p73和p53蛋白在20例良性、9例交界性、31例恶性肿瘤中的表达。结果:p73蛋白在良性肿瘤无表达(0/20);在交界性肿瘤和恶性肿瘤中的阳性表达率分别为22.22%(2/9)和41.94%(13/31),差异具有显著性(P<0.05)。恶性肿瘤组内p73蛋白的表达与组织的分化相关(P<0.05),与不同的临床分期无相关性(P>0.05)。p53蛋白在良性、交界性、恶性肿瘤中的表达率分别为0(0/20)、11.11%(1/9)、51.61%(16/31),差异有显著性(P<0.05)。恶性肿瘤组内p53蛋白的表达与组织的分化程度和肿瘤的临床分期无明显相关性(P>0.05)。结论:p73基因以高表达方式参与卵巢上皮性肿瘤的发生发展;突变型p53基因的高表达可作为判断卵巢上皮性肿瘤良、恶性的指标之一。更多还原

【Abstract】 Objective: To study the expression of p73 and p53 protein and to ana lyze their roles in epithelial ovarian tumors.Methods: T he expression of p73 a nd p53 protein in 20 cases of benign ovarian tumor, 9 cases of borderline ovaria n tumor and 31 cases of ovarian carcinoma was analyzed by immunohistochemical te chnique. Results: The expression of p73 protein was nega tive in benign ovarian t umors (0/20), 22.22%(2/9) positive in borderline tumors and 41.94%(13/31) in ova rian epithelial malignant tumors. There was obvious differences in the expressio n of p73 among the three groups(P<0.05). In the malignant tumor group, the p ositive expression of p73 was closely correlated with tumor differentiation (P <0.05) , but had no relation to clinical stage (P>0.05). The positive expression r ate of p53 protein was 0(0/20)、11.11%(1/9)、51.61%(16/31) in benign、borderline a nd malignant ovarian epithelial tumors, respectively, which had significant diff erences among them (P<0.05).The expression of p53 protein had no relationshi p with tumor differentiation and clinical stage in ovarian cancer (P>0.05). Conclusions: p73 gene takes part in the development of m alignant epithelial ovari an tumors with high expression. The type of mutant p53 gene may be used as an in dicator of judging benign and malignant tumors in epithelial ovarian tumors.更多还原