【摘要】 目的研究结核患者细胞因子变化规律和调控机制,以帮助临床鉴别诊断。方法对54例结核患者、18例肺癌患者和12例健康人血清、肺泡灌洗液、胸水及脑脊液等多种标本的各种细胞因子进行检测。结果结核患者血清白介素(IL)-12、IL-18等T h1细胞因子及IL-10、IL-4等T h2细胞因子水平均较高。各种细胞因子在脑脊液中含量均较低;干扰素γ(IFN-γ)在胸水渗出液中含量很高。前炎性因子IL-6、IL-8和肿瘤坏死因子-α(TNF-α)在结核患者中水平较高。IL-10与TNF-α的比值在结核和肿瘤患者之间有显著差异。结论细胞因子检测有助于结核病和肺癌患者的鉴别诊断。更多还原

【Abstract】 Objective: To determine different cytokine levels in different samples of tuberculosis cases.Methods: Sera,pleural fluid,BALF and CSF were obtained from a total of 54 tuberculosis cases,18 lung cancer cases,and 12 healthy individuals.Different cytokines including Th1 cytokines(IL-12,IL-18 and IFN-γ),Th2 cytokines(IL-4 and IL-10),pro-inflammatory cytokines(IL-6,IL-8,andTNF-α) and some cytokine receptors(IFN-γR and IL-12R) were detected.Results:IL-12,IL-18,IL-10 and IL-4 showed higher levels in tuberculosis patients.The levelsof most cytokines in CSF were very low,but a high level of IFN-γ was observedin pleural fluid.The pro-inflammatory cytokines,IL-6,IL-8 and TNF-α,were detected at a higher level in tuberculosis cases.Ratio of IL-10 and TNF-α hadasignificant difference between tuberculosis and lung cancer cases.Conclusion: Cytokines detection can be used for a tuberculosis and lung cancer differential diagnosis.更多还原