【摘要】 目的探讨5-羟色胺(5-HT)在支气管哮喘(下称哮喘)豚鼠气道重塑中的作用机制。方法将50只雄性豚鼠随机分为正常对照组(A组)、哮喘模型组(B组)、哮喘模型延续组(B1组)、5-HT组(B2组)、5-HT拮抗剂组(B3组)。用卵清蛋白复制哮喘气道重塑模型。观察血清5-HT浓度和气道壁各层厚度。结果①血清5-HT浓度与气道壁各层厚度B组明显大于A组,B1组明显大于B组,P<0.05,<0.01。②气道壁各层厚度B2组大于B1组,B3组小于B1组,P均<0.05。结论5-HT浓度变化是哮喘豚鼠气道重塑的机制之一。更多还原

【Abstract】 Objective:To explore the mechanisms of 5HT on the airway remodeling of bronchial asthma in guinea pigs.Methods:50 guinea pigs were divided into 5 groups:normal group（A group）,asthma model group（B group）,continued asthma model group（B₁ group）,5-HT group（B₂ group）,anti-5-HT group（B₃ group）.Remodeling models of asthma were established with ovalbumin.Results:In B group,concentration of 5-HT in serum and thicknesses of airway mucosa,base membrane,smooth muscle were significantly increased compared with A group（P<0.05,<0.01）.In B₁ group,concentration of 5-HT and thicknesses of airway walls were significantly increased compared with B group（P<0.05,<0.01）.Thicknesses of airway walls in B₂ group were greater than those of B₁ group（P<0.05）.Thicknesses of airway walls in B₃ group were smaller than those of B₁ group（P<0.05）.With the aggravation of airway remodeling,lungs/weight and brain/weight were upward.Conclusion:5-HT is one of the mechanisms of the airway remodeling of bronchial asthma in guinea pigs.更多还原