【摘要】 目的观察妊娠高血压综合征(妊高征)患者胎盘组织中生存素(surv iv in)的表达情况,探讨其在妊高征发病中的作用。方法采用免疫组化SP法检测正常及妊高征孕妇胎盘组织中surv iv in的表达,并采用计算机图像分析系统进行定量分析。结果surv iv in蛋白主要位于绒毛小叶的合体滋养细胞及细胞滋养细胞,也存在于羊膜绒毛层。妊高征组胎盘滋组织surv iv in的平均光密度值为0.324±0.033,且随病情加重而减少,较正常胎盘的0.390±0.042显著降低(P<0.05).结论胎盘组织中surv iv in的减少可能与妊高征的发生发展有关。更多还原

【Abstract】 Objective:To observe the expression of survivin in placenta and to evaluate its role in the pathogenesis of pregnancy induced hypertension(PIH).Methods:The survivin in normal and PIH placenta was determined by immunohistochemistry.The mean density was determind by image analysis technique.Results:Survivin was mostly found in syncytiotrophoblast,cytotrophoblast and amnio chorion.The strongest imuo reactivity was observed in the syncytiotrophoblast and cytotrophoblast.The mean density of survivin in PIH placenta(0.324±0.033)was significantly lower than that in normal placenta(0.390±0.042),P<0.05.Conclus-ion:Reduced survivin expression in placenta may have an important role in the pathogensis in PIH.更多还原