【摘要】 目的探讨血清总前列腺特异抗原(tPSA)、游离PSA(fPSA)与tPSA的比值(F/T)、前列腺特异抗原密度(PSAD)在前列腺增生(BPH)和前列腺癌(PCa)鉴别诊断中的价值。方法检测65例BPH患者及38例PCa患者的血清tPSA、fPSA,经腹部B超测定前列腺的前后径、左右径、上下径,并计算出F/T、前列腺体积(PV)及PSAD,进行比较。结果在灰区外高值区,tPSA、PSAD在两组间差异有显著性(P均<0.01),F/T差异无显著性(P>0.05);在灰区,两组间tPSA差异无显著性(P>0.05),而F/T、PSAD差异有显著性(P均<0.01);在灰区外低值区,tPSA、F/T及PSAD在两组间差异无显著性(P>0.05)。结论以F/T及PSAD作为tPSA的辅助指标,对PSA灰区PCa的诊断具有明显临床意义。更多还原

【Abstract】 Objective:To study the value of serum total prostate specific antigen (tPSA),the ratio of free prostate specific antigen (fPSA) and tPSA (F/T),prostate specific antigen density(PSAD) in the differential diagnosis of benign and malignant prostatic diseases.Methods:The tPSA,fPSA and prostatic volume were analysed in 38 prostate cancer and 65 BPH patients.The F/T ratio and PSAD were obtained.The tPSA,F/T ratio and PSAD in patients both within and outside the gray zone were analysed.Results:tPSA and PSAD were significantly different between patients with prostate cancer and BPH (P<0.01 both) when the assessed level were much higher beyond gray zone.When the assessed level were within the gray zone,the F/T and PSAD were different between the two condition (P<0.01).However,tPSA,F/T and PSAD had no significant differences between the two conditions (P>0.05) in the lower value range beyond the gray zone.Conclusion: The F/T ratio and PSAD are adjuvant markers to tPSA,and have clinical significance in differential diagnosis on patients whose tPSA in diagnostic gray zone.更多还原