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硫普罗宁注射液安全性试验
Experiment for security evaluation of Tiopronin Injection
【摘要】 目的评价硫普罗宁注射液的安全性。方法对硫普罗宁注射液进行血管刺激性、溶血性、过敏性试验。结果硫普罗宁注射液对家兔耳缘静脉无明显刺激作用,对家兔红细胞无明显体外溶血及致凝集作用,对豚鼠无致过敏作用。结论硫普罗宁注射液用于注射是安全的。
【Abstract】 Objective To study the security of Tiopronin Injection.Methods The stimulation reaction of Tiopronin on blood vessel of rabbit,the hemolysis and agglomeration reaction on vitro-body red cell of rabbit and the hypersensitivity reaction on Guinea pig were studied.Results The results showed no stimulation on blood vessel of rabbit,no hemolysis and agglomeration on vitro-body red cells of rabbit and no hypersensitive action on Guinea pig.Conclusion Tiopronin is safe for injection.
【关键词】 硫普罗宁;
血管刺激性;
溶血性;
过敏性;
【Key words】 Tiopronin; stimulation on blood vessel; hemolysis; hypersensitivity;
【Key words】 Tiopronin; stimulation on blood vessel; hemolysis; hypersensitivity;
- 【文献出处】 齐鲁药事 ,Shangdong Pharmaceutical Industry , 编辑部邮箱 ,2005年08期
- 【分类号】R96
- 【被引频次】3
- 【下载频次】142