【摘要】 目的:探讨癫痫大鼠发作前后脑内免疫状态和经免疫球蛋白(IVIg)干预处理后其肿瘤坏死因子-α(TNF-α)和白细胞介素-2、4、10(IL-2、4、10)等细胞炎性因子的变化。方法:用印防已毒素(PTX)制备癫痫大鼠模型,在发作前、后分别给予IVIg进行干预处理,检测脑组织匀浆内TNF-α和IL-2、4、10的浓度变化,并与对照组比较。结果:癫痫大鼠发作后其脑内TNF-α和IL-2、IL-4、IL-10的水平显著升高,给予IVIg干预后,这4项炎性细胞因子水平明显低于模型对照组(P<0.01)。结论:癫痫大鼠发作后脑内某些与免疫反应相关的炎性细胞因子水平升高,而IVIg则能降低大鼠脑内免疫反应强度,从而抑制大鼠的癫痫发作。更多还原

【Abstract】 Objective: To investigate the effect of immunoglobulin on epilepsy rat with detecting the content of intracerebral TNF-α and interleukins-2,4 and 10. Methods: Prepared the epilepsy model of rat with picrotoxin (PTX) injection, then it was interfere the model with immunoglobulin injection either before or after seizure respectively. The content of intracerebral TNF-α and interleukins-2,IL-4 and IL-10 in experimental group were detected, and compared with those of control group. Results: The contents of TNF-α and interleukins-2,IL-4 and IL-10 were significantly increased after seizure. After interfered with immunoglobulin, they were significantly lower than those of the control group. Conclusion: The contents of TNF-α and interleukins-2, IL-4 and IL-10 significantly increase after seizure, and the immunoreaction can be decreased by immunoglobulin injection, consequently the seizure of epilepsy rat is controlled.更多还原