【摘要】 采用亚胺基氯化物法,制备头孢克肟的中间体7-氨基-3-乙烯基-头孢烷酸对甲氧基苄酯盐酸盐。7-苯乙酰胺基-3-氯甲基-头孢烯酸对甲氧基苄酯经3位Wittig反应后用亚胺基氯化物法脱去7位侧链,得目的产物。反应条件温和,周期缩短,总收率70%。更多还原

【Abstract】 Synthesis of AVNA (7-amino-3-vinylcephem-4-carboxylic acid) from GCLE (7-phenylacetamide-3-chlorormethylcephem-4-carboxylic acid p-m-ethoxybenzyl ester) includes 2 steps:converting GCLE into GVNE (7-phenylacetamide-3-vinyl-3-cephem-4-carboxylic acid p-m-ethoxybenzyl ester) using Wittig Reaction,and then converting GVNE into AVNA using “iminochloride" compound.更多还原