【摘要】 目的 :观察紫杉醇联合顺铂治疗局部复发或 /和远处转移中晚期鼻咽癌的疗效和毒副反应。方法 :经病理组织学或细胞学诊断的局部复发或 /和远处转移的中晚期鼻咽癌患者 2 0例 ,用紫杉醇 135mg/m2 ,静脉滴注持续 4小时 ,第 1天给药 ;DDP 80mg/m2 静脉滴注 ,分两天用 (第 1天、第 2天 ) ,2 1天为一周期 ,所有病例均至少接受2个周期化疗。结果 :CR 1例 ,PR- 12例 ,总有效率 6 5 . 0 %。主要毒副反应为骨髓抑制 ,恶心、呕吐 ,脱发 ,肌肉及关节疼痛等。结论 :紫杉醇联合顺铂方案治疗局部复发或 /远处转移的鼻咽癌有较高的有效率 ,毒副反应较小 ,值得临床进一步研究。更多还原

【Abstract】 Objective:To observe the efficacy and toxicities of paclitaxel and DDP for advanced nasopharyngeal carcinoma(NPC).Methods:The 20 Patients with a histologic diagnosis of NPC were eligible.The chemotherapy regimen was comprised of paclitaxel 135 mg/m2 infusion for 4 hours,DDP 80 mg/m2 infusion d 1～2 ,repeated every 3 weeks.All patients received at least two cycles of the treatment.Results:The response rates was 65.0%,including CR 1,PR 12.The major toxicity included neutropenia、nausea vomiting、arthralgia、myalgia and alopecia.Conclusion:Paclitaxel combine with DDP is an effective therapy with acceptable adverse reactions for advanced NPC. It merit further studies.更多还原