【摘要】 目的观察TP方案新辅助化疗治疗Ⅲ、Ⅳ期乳腺癌的疗效及不良反应。方法紫杉醇135m g/m2,静滴3h,顺铂25m g/m2静滴,均第1天完成;共6～9个疗程,且在第2疗程后3周按乳腺癌根治术方式行手术切除治疗。结果CR18例(Ⅲ期15例,Ⅳ期3例),PR17例(Ⅲ期12例,Ⅳ期5例),NC6例(Ⅳ期),PD1例(Ⅳ期);有效率RR(CR+PR)83.3%。主要不良反应为骨髓抑制、肌肉关节疼痛、胃肠道反应及周围神经痛。结论TP方案新辅助化疗治疗Ⅲ、Ⅳ期乳腺癌的疗效肯定,不良反应可耐受。更多还原

【Abstract】 Objective To observe curative and adverse effects of treatment of TP neoadjuvant chemotherapy regimen in mammary glands cancers in periods III and IV assisted with TP project. Methods Intravenous drip of 135 mg/m2 of TAXOL and PDD 25 mg/m2 for 3 hours was done in the first day of each period in the total 6～9 periods of treatment, and radical excision of cancerous mammary glands was made at second or third chemical treatment periods. Results It was found that there were 18 CR cases (15 cases at period III and 3 cases at period IV), 17 PR cases (12 cases at period III, 5 cases at period IV), 6 NC cases at period IV, 1 PD case at period IV, and that the efficient RR (CR+PR) was 83.3%. Adverse effects included marrow inhibitation, pains of muscle and joint, gastrointestinal reaction and peripheral neuralgia. Conclusion TP neoadjuvant chemotherapy regimen cures the cancerous mammary glands at period III and IV well with tolerable adverse effects.更多还原