【摘要】 目的探讨血管紧张素转换酶(angiotensin converting enzym e,ACE)基因与脑出血发病的关系。方法应用聚合酶链反应方法检测150名健康人(norm otensive controls,NT)及60例高血压合并脑出血患者ACE I/D基因多态性。结果脑出血患者的DD基因型及D等位基因频率和正常对照组比较差异有显著意义(P<0.05)。结论ACE基因DD基因型和D等位基因携带者可能是高血压合并脑出血的易感因素。更多还原

【Abstract】 Objective To identify the I/D polymorphism of angiotensin converting enzyme (ACE) in hypertension patients complicated with intracerebral hemorrhage. Methods ACE genotyping with polymerase chain reaction (PCR) were used to detect ACE gene I/D polymorphism in 152 controls and 60 hypertensive patients complicated with intracerebral hemorrhage. Results The frequencies of the ACE D allele in groups of hypertension complicated with intracerebral hemorrhage were higher than that in the health controls,(P < 0.05). Conclusion ACE gene DD homozy-gosity of the I/D polymorphism in intron 16 is an independent risk factor for hypertension complicated with intracerebral hemorrhage.更多还原