【摘要】 为探讨周小剂量卡铂(CBP)联合低剂量氟脲嘧啶治疗>65岁高龄晚期结肠癌的临床疗效和毒副反应,将高龄晚期结肠癌患者29例随机分成两组,治疗组15例:每周每次采用静脉输注小剂量CBP100mg/m2,联合低剂量5-氟尿嘧啶500mg/m2,连续3周,休1周;重复3个周期;对照组14例采用静脉输注CBP300mg/m2,d1,联合5-氟尿嘧啶500mg/(m2·d),d1~d5,每28d重复,重复3个周期。3个周期后进行临床评价。结果显示,治疗组15例,总有效率为46·7%,其中CR0例,PR7例;对照组14例;总有效率为42·9%,其中CR0例,PR6例;P>0·05;毒性反应,治疗组:消化道Ⅰ~Ⅱ度以上反应1例,Ⅰ度白细胞下降1例,共占13·3%;对照组:消化道Ⅱ度以上反应6例;Ⅰ度以上白细胞下降3例,共占64·3%,P<0·05。初步研究结果提示,周小剂量CBP联合低剂量5-氟尿嘧啶可能是治疗。更多还原

【Abstract】 To evaluate the efficacy and toxicity of treatment of advanced colorectal cancer in older patients with weekly low dosage. Methods: 29 older patients with advanced colorectal cancer were randomly divided into two groups. The treated group （n=15） received CBP100 mg/m²/w,iv,gtt,week 1,2,3; and 5-FU 500 mg/（m²·w）,iv,gtt, week 1,2,3; The second treatment cycle was given after 1 week,at last 3 cycle were given; the dontrol group （ n= 14） received CBP 300 mg/（m²·d₁） iv,gtt.and 5-FU 500 mg/（m²·d 1-5 ）; The second treatment cycle was given after 28 days,at last 3 cycle were given; Result: In the treated group, the overall response rate was 46.7%; the major toxic effect rate （grade Ⅰ-Ⅱ） was 13.3%; the toxic effect were myelosuppression and symptoms of gastrointestinal side-effects. In the contral group, the overall response rate was 42.9%,P>0.05; the major toxic effect rate （grade Ⅰ-Ⅱ） was 64.3%,P<0.05; Conclusion: Weekly low dosage of chemotherapy has as the response rate as the chemotherapy with route dosage. The toxic effect in the treated group were lower than in the contral group. The therapy is tolerable in the patients older with advanced colorectal cancer.更多还原