【摘要】 通过对葡萄胎绒毛膜促性腺激素(human chorionic ganadotropin,HCG)的计量学相关性研究,探讨侵袭性葡萄胎血清HCG-β含量高于良性葡萄胎的原因。采用免疫组化、组织学图象分析定量、血清HCG-β检测,对32例良性葡萄胎和21例侵袭性葡萄胎HCG含量进行测定。结果示良性葡萄胎合体滋养细胞单位面积HCG含量(0·560±0·064)明显高于侵袭性葡萄胎(0·409±0·122);而侵袭性葡萄胎HCG阳性胞质所占面积比率(0·284±0·136)显著高于良性葡萄胎(0·159±0·076);但组织中HCG相对总量二者差异无统计学意义,血HCG-β(ng/mL)含量有明显不同,良性葡萄胎(165·14±35·0),侵袭性葡萄胎(248±15·9);初步研究结果提示,虽然良性和侵袭性葡萄胎组织中HCG相对总量差异无统计学意义(P>0·05),但侵袭性葡萄胎HCG分泌功能细胞数目增多和侵袭组织接触HCG释放表面积的明显增大,使血HCG-β含量增高,反映了生物学行为的侵袭性。更多还原

【Abstract】 To investigate the reason which HCG-β content in serum is higher in invasive mole than benign mole by study on quantitative HCG and hydatidiform mole. HCG-β in serum, HCG content and rate of HCG positive plasma in 32 cases of benign mole, 21 cases of invasive mole were studied using immunohistochemistry, microspectroscopeic image analysis method and radioimmunoassay. The HCG content of syneytiotrophoblast was higer in benign mole(0.560±0.064) than invasive mole (0.409±0.122); The rate of HCG positive plasma was higher in invasive mole (0.284±0.136)than benign mole (0.159±0.076); The difference of HCG total content was not found between them,P>0.05; HCG-βin serum was rising more in invasive mole (248.16±15.9) than benign mole (165.14±35); Though HCG content in tissue of mole were not different, invasive mole which function cell and surface area was increased showed higher HCG-βin serum. It’s evidenced that invasive mole was more malignant.更多还原