【摘要】 目的:评价奥沙利铂、5氟尿嘧啶(5FU)和甲酰四氢叶酸(CF)联合新辅助化疗治疗局部进展期胃癌的近期疗效和毒副反应。方法:选择2000年3月～2004年4月我科住院的胃癌患者42例入组,术前接受化疗,方案为:奥沙利铂130mg/m2,d1;5FU500mg/m2,d1～d3;CF300mg/d,d1～3。每3个周为1个周期,共2个周期。观察新辅助化疗后肿瘤原发病灶的缓解情况,并观察毒副反应。结果:42例患者中有38例获得手术切除,其中26例获得根治性切除,19例肿瘤原发病灶明显缩小,14例肿瘤TNM分期降低。毒副反应主要为白细胞减少、腹泻、恶心、呕吐、脱发、肝功能异常,经对症及营养支持治疗后均能缓解。结论:奥沙利铂联合5FU与CF新辅助化疗在局部进展期胃癌的治疗中近期疗效显著,耐受性良好。更多还原

【Abstract】 OBJECTIVE:To evaluate the effects and toxicity of Oxaliplatin and 5-FU plus CF as the neoadjuvant chemotherapy in the treatment of locally advanced gastric cancer. METHODS: From March 2000 to 2004, 42 cases of locally advanced gastric cancer patients were treated with Oxaliplatin/5-FU/CF chemotherapy before operation. Neoadjuvant chemotherapy regimens containing Oxaliplatin 130 mg/m 2 (day 1) plus 5-FU 500 mg/m 2 (day 1 to 3) and CF 300mg/d (day 1 to 3) were administered every 3 weeks for 2 cycles before operation. The response in the primary tumor and the chemotherapy toxicity was observed in each patient. RESULTS: 14 of the 42 patients were downstaged, and subtotal or total gastrectomy was carried out in 38 patients; 26 patients were operated completely, primary tumor was reduced efficiently in 19 patients. The most common toxicities were leukocytopenia, nausea, vomiting, alopecia and hepatosis. The toxicities relieved after symptomatic treatment. CONCLUSION: The combination of Oxaliplatin and 5-FU and CF is an effective and well-tolerated regimen as neoadjuvant chemotherapy for the locally advanced gastric cancer.更多还原