【摘要】 目的探讨尿蛋白阴性糖尿病患者随机尿中三种微量蛋白和NAG酶联合检测在临床诊断早期肾损伤的应用价值。方法测定73例2型糖尿病患者和40例健康查体者尿中微量白蛋白(MALB)、转铁蛋白(TF)、β2-微球蛋白(β2-MG)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG),同时检测尿肌酐作对比,保证结果准确性。三种微量蛋白采用免疫比浊法,NAG采用终点法。结果糖尿病患者TF、MALB、β2-MG、NAG明显高于正常对照组(P<0.01);四项联合检测阳性率达93.1%,明显高于单项检测。结论TF、MALB、β-MG、NAG检测是诊断糖尿病早期肾损伤的敏感指标,肾小管损伤早于肾小球。更多还原

【Abstract】 Objective To study the clinical value of three urinary trace proteins and NAG in the diagnosis of earlier diabetic nephropathy（DN） of DM whose urinary protein is negtive. Method Urinary mircroalbumin、transferrin、β₂-microglobumin and N-acety1-β-D-glucosmnccharase in 73 patients with type 2 diabetes and 40 health subjects were measured by immunitytuibidimetry assay and end-point method assay and compared with their urinary critinine,to assure veracity. Result Campared with health control group,in DM group urinary three trace proteins and NAG are patently higher（P<0.01）,and their detennination together is significantly higher than single one（93.1%）。 Conclusion Urinary TF、MALB、β₂-MG and NAG are sensitive items;Detemination together increase greatly the diaganositic rate of DN;The damage of glomemlus is earlier than that of glomemlus.更多还原