【摘要】 目的了解血管性痴呆(VaD)患者外周血中白介素IL-2、IL-6及IL-8的表达特征。方法以酶标法测定VaD患者45例及无智能障碍脑血管病患者48例外周血中IL-2、IL-6及IL-8含量并比较其差异。结果VaD组患者外周血中IL-2、IL-6及IL-8的含量与对照组间差异有显著性意义(P<0.01),且降低的水平与痴呆的严重程度呈正相关。结论VaD患者外周血中细胞因子含量与普通脑卒中患者间差异有显著性意义,提示细胞免疫及炎性反应可能介入了血管性痴呆的发病机制。更多还原

【Abstract】 Objective To explore the diffence serum leval of IL-2、IL-6 and IL-8 in patients of vascular dementia.Methods IL-2、IL-6 and IL-8 was checked in patients of cerebral vascular disease with vascular dementia(VaD) and those stroke patients without cognitive decrease,and explore the possible effection of inflammatory response in the mechanism of VaD.Results The patients of VaDs showed higher leval of IL-2 and IL-6 than stroke patients without dementia,otherwaithIL-8 shewed lower leval in VaD patients than in general stroke patients.Conclusion The serum leval of interleukin in VaD patients are defferent form general stroke patients.it implied cell immunology may play a role in the methamism of Vascular dementia.更多还原