【摘要】 目的探讨原发性胆囊癌组织中环氧合酶-2(COX-2)的表达与术后脏器转移的关系。方法应用免疫组织化学方法检测39例原发性胆囊癌组织中COX-2的表达情况,结合术后随访结果进行分析。结果COX-2表达阳性患者术后1年内肝、肺转移率为96.6%,COX-2表达阴性患者肝、肺转移率2/10,二者间差别有显著性意义(P<0.05)。结论COX-2表达阳性患者原发性胆囊癌术后脏器转移率明显高于表达阴性者,临床可采用高选择性COX-2抑制剂进行术后的化学防治。更多还原

【Abstract】 Objective To study the expression of COX-2 in primary gallbladder carcinoma and the relation with the postoperative metastasis of organ,and to supply the theoretical base for the chemotherapy of the relation with the primary gallbladder carcinoma.Methods COX-2 protein was analysed in 39 cases of primary gallbladder carcinoma,by immunohistochemistry examining multiclonal antibody of COX-2,and it was analysed that postoperative result of follow-up survey.Results Postoperative metastasis rates of positive cases of COX-2 was 96.6%(28/29),and it was significantly higher than non-positive cases of COX-2 (20%,2/10)(P<0.05).Conclusion The positive expression of COX-2 in primary gallbladder carcinoma was obviously higher than the non-positive expression in the postoperative metastasis of organ.COX-2 with higher choice can be used clinically in chemotherapy after operation.更多还原