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Alzheimer病认知障碍和非认知功能改变的相关性

Relationship between Cognitive Disturbances and Non-Cognitive Function in Alzheimer′s Disease

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【作者】 王晓平胡凤仪谭忠林陈凯杨兴涛赵永波周江宁

【Author】 WANG Xiao-ping, HU Feng-yi, TAN Zhong-lin, et al. Department of Neurology, The First Hospital of Shanghai Jiaotong University, Shanghai 200080, China

【机构】 上海交通大学上海第一人民医院神经科安徽省合肥城建医院老年院中国科技大学神经退行性疾病研究室中国科技大学神经退行性疾病研究室 200080上海市200080上海市

【摘要】 目的 对Alzheimer病 (AD)的非认知行为障碍和认知障碍进行相关性研究。方法 符合DMS -Ⅳ等临床诊断标准的Alzheimer病患者 32例 ,对患者实施简易智力状态检查量表及神经精神量表测试。结果 神经精神量表 12个项目的发生率排序为淡漠 (84 38% )、机械刻板 (78 13% )、夜眠障碍 (78 13% )、食欲体重改变 (6 2 5 0 % )及亢奋欣快 (4 0 6 3% )等 ,而激越攻击的发生率为 37 5 0 %。AD患者淡漠和认知障碍程度高度相关 ;幻觉、激越攻击和忧郁难过与认知障碍程度呈负相关 ,提示在痴呆相对较轻的患者其幻觉、激越攻击和忧郁难过症状反而更为明显。结论 神经精神量表中部分项目和认知功能减退相关

【Abstract】 Objective To investigate the relationship between non-cognitive behavior disturbances and cognitive disturebances by neuropsychiatric inventory(NPI)and MMSE scores in Alzheimer′s disease (AD).Methods 32 AD patients identified by DMS-Ⅳ and MMSE, the caregivers were interviewed by NPI. The frequency and severity of 12 behaviors were assessed.Results All patients were assessed in delusion, hallucination, agitation, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability, aberrant motor, nighttime disturbances and appetite/eating disturbances. Relationship among 12 items and their correlations with cognitive impairment were also investigated. All symptomatic behaviors were markedly increased, and the most common is apathy, followed by aberrant motor, nighttime disturbances, appetite/eating disturbances and euphoria,but agitation occupied with 37.50%.Conclusion Apathy, agitation, dysphoria and hallucination behaviors were significantly correlated with cognitive deficits.

【基金】 国家 973计划资助项目 (G1 9990 54)
  • 【文献出处】 中国全科医学 ,Chinese General Practice , 编辑部邮箱 ,2005年03期
  • 【分类号】R749.16
  • 【被引频次】8
  • 【下载频次】131
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