Objective To measure telomere length by hybridization with non-radio-isotopic-labeled probes, so as to study the effect of donation on hematopoietic system.Methods The high-molecular weight genomic DNA was prepared by standard method and digested, then hybridized by digoxin-labeled probes.The mean telomere length was calculated by scanning the exposed X-ray film with a densitometer. Result The TRF of 35-40 years old donors and nondonors were 11.73Kb and 11.78Kb,respectively. Conclusion A digoxin-labeled and...
【更新日期】
2005-11-25
【分类号】
R446.9
【正文快照】
端粒穴telom ere雪是真核细胞染色体末端的一种特殊蛋白质-D N A结构,其功能是维持染色体的稳定,使染色体免遭融合、重组和降解眼1,2演。其中的重复TTA G G G序列会随着细胞的有丝分裂而缩短,与衰老和肿瘤的发生有着密切的关系眼3,4演。长期的固定无偿献血必然会刺激骨髓的造血
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