【摘要】 目的研究吲达帕胺缓释片在体内外的相关性。方法应用释放度测定法研究吲达帕胺缓释片的体外释药行为,用LC–MS法测定吲达帕安缓释片在人体内的血药浓度,按Wanger-Nelson公式计算药物吸收百分数,并与相应时间体外累积溶出度线性回归,进行体内外相关性考察。结果吲达帕胺缓释片体内药动学特征符合单室一级吸收模型,血药浓度在24 h内表现平稳。以体内吸收百分率(Y)与体外释放百分率(X)建立线性回归方程:Y=0.8991X–2.282,r=0.9945(P<0.01)。结论吲达帕胺缓释片体外释放百分率和体内吸收百分率呈显著相关。更多还原

【Abstract】 Objective To study the in vitro and in vivo correlation of indapamide sustained-release tablets.Methods The release tests in vitro were used to evaluate the behavior in vitro of the sustained-release tablets. LC-MS was applied for determining concentration of indapamide in human blood. The correlation was studied between the dissolution test in vitro and the absorption in vivo calculated by Wanger-Nelson method. Results Indapamide sustained-release tablets coincided with one-compartment model and provided a persistent blood drug level for at least 24 h. The linear regressive equation was established between the absorption rate in vivo and the accumulating release rate in vitro of indapamide. Conclusions There is a significant correlation between the absorption in vivo and the release in vitro of indapamide sustained- release tablets.更多还原