【摘要】 目的制备对乙酰氨基酚缓释微丸,并进行释放度考察。方法采用粉末层积法以离心造粒技术制备载药微丸,以丙烯酸树脂Eudragit NE30D为包衣液包覆缓释衣层,制成膜控缓释微丸,考察聚合物增重、后处理方法及致孔剂等因素对缓释微丸释放度的影响。结果致孔剂可改善缓释微丸的时滞现象,药物释放速度随膜厚及后处理时间的增加而变慢。结论对乙酰氨基酚缓释微丸具有较好的释药性能,是一种较理想的口服缓释制剂。更多还原

【Abstract】 Objective To prepare paracetamol sustained-release pellets and study its release characteristics.Methods The centrifugal coating and granulating equipment were used to prepare pellets,with Eudragit NE30D as sustained-release coating material.The effects of the coating level,the amount of poremaking agent and curing time on the paracetamol release rate from paracetamol sustained-release pellets were studied.Results The coating level,the amount of poremaking agent and curing time can alter the drug release rate.Conclusions It is indicated that paracetamol sustained-release pellets have a good sustained-release property.更多还原