【摘要】 二氢沉香呋喃倍半萜具有杀虫、抗炎、抗肿瘤等多种生物活性。我们由山道年出发,开拓了一条全新的、简洁的合成二氢沉香呋喃倍半萜骨架的方法,获得了一系列新化合物。采用菌丝生长速率测定法,初步研究表明,桉烷类倍半萜化合物对瓜果腐霉菌、辣椒疫霉菌、茄子立枯病菌、瓜类枯萎病菌、番茄灰霉病菌等植物病原真菌均有一定的生物活性。SHI06和SHI07号化合物在200mg/L时对瓜果腐霉菌的抑制活性高于90%,如果进一步进行结构改造,有望开发成为一类新型仿生合成的杀菌剂。更多还原

【Abstract】 Sesquiterpenoids have a variety of biological activities including insecticidal, anti-inflammatory, and anti- oncogenicity. We developed a new and simple framework for synthesizing sesquiterpenoids and obtained a series of new compounds. Preliminary studies using a mycelial growth method indicated inhibitory activity at 100 to 200 mg/L against pathogenic fungi such as Pythium aphamidermatum, Phytophthora capsici, Fusarium oxysporum, Rhizoctonia solani, and Botrytis cinerea. New compounds, SHI 06 and SHI 07, showed good efficacy against Pythium aphamidermatum, with >90% inhibition at 200 mg/L. These compounds have potential for development as a new group of fungicides.更多还原