【摘要】 目的:探讨外源性雌激素对冠心病致病因子作用的研究现状。方法:阅读国内外大量相关文献,并加以归纳总结,得出结论。结果:血脂代谢紊乱、炎症反应、凝血及纤溶系统异常、血管内皮功能障碍是冠心病发病的重要致病因素,它们分别以高TDL、LC、TG、低HDL、C-反应蛋白升高、纤维蛋白原升高、内皮素升高等作为致病因子,导致冠心病的发生。雌激素的心血管保护作用是通过影响血脂、凝血和纤溶系统、血管的炎症反应、血管内皮细胞的功能等冠心病致病途径而实现的。结论:雌激素对心血管系统具有保护作用,外源性雌激素可通过影响冠心病致病因子,阻止冠心病的发生,绝经后妇女雌激素替代治疗对冠心病的发生有一定的预防作用。更多还原

【Abstract】 Objective:To investigate the effect of exogenous estrogen on the causative agent of coronary artery disease(CAD).Methods:Reading and summarizing literatures home and aboard,then drawing a conclusion.Results:Lipid metabolism disorder,inflammatory reaction,the abnormal blood clotting and fibrinolysis system and blood vessel endothelium fuctional disturbance were important causative agents of CAD.Higher LDL,higher TC,higher TG,lower HDL,higher C-reactive protein,higher FIB,higher endothelin involved in CAD.Estrogen replacement therapy(ERT) could reduce the risk of angiocardiopathy by affecting blood fat,inflammatory reaction,the blood clotting and fibrinolysis system and fuction of blood vessel endothelium.Conclusion:Estrogen plays protective role in cardiovascular system.Exogenous estrogen can prevent the development of CAD by affecting the causative agent of CAD.ERT contributes to the genesis of CAD in post-menopause women.更多还原