【摘要】 目的:评价盐酸地尔硫卓(合贝爽)注射剂在治疗围手术期高血压中的有效性和安全性。方法:开放性病例收集研究。共收集23例非心脏外科手术合并有高血压的患者。先以(5～10)μg/(kg·min)静脉滴注或泵入,每5min递增5～10μg/(kg·min),平均点滴速率在30min内渐增至10～20μg/(kg·min)。观察血压和心率的变化。结果:治疗前与治疗后不同时间段对收缩压(SBP)、舒张压(DBP)以及心率(HR)的作用效果分别为:从治疗前的SBP/DBP210.8±19.6/128.4±10.3(mmHg)至治疗后10min的SBP/DBP186.4±15.3/93.1±11.2(mmHg),和用药前相比P<0.05;治疗后60min:SBP/DBP158.3±14.7/84.3±8.3mmHg,和用药前相比P<0.001。给药前与给药后各时间段的心率无显著性改变(用药前HR:88.6±18.6次/min,用药后60min81.4±14.9次/min),P>0.05。结论:地尔硫卓注射剂治疗围手术期重症高血压安全有效。更多还原

【Abstract】 Objective: To evaluate the antihypertensive effect and safety of continuous intravenous diltiazem infusion in perioperative patiente with severe hypertension. Methods:Opened clinical trial. Twenty-three peri-operative noncardiac surgery patients with hypertension were studied. Intravenous diltiazem was administered firstly with infusion of 5~10 μg/(kg·min), or with micro-syringe, then gradually increase 5~10 μg/(kg·min) every 5 minutes, until the dosage up to 10~20 μg/(kg·min) within 30 minutes. The changes of SBP, DBP and heart rate were observed. Results:The blood pressure and heart rate were monitored and compared before and after 10, 60minutes of intravenous diltiazem infusion. The effect on blood pressure was significant, SBP/DBP was gradually dropped from {210.8}±{19.6}/{128.4}±{10.3}(mmHg) to {186.4}±{15.3}/{93.1}±{11.2} (mmHg) after 10 minutes (~*P <{0.05}) and {158.3}±{14.7}/{84.3}±{8.3} (mmHg) after 60 minutes respectively (~{**}P <{0.001}). At the same time HR and ECG didn’t change obviously ({88.6}±{18.6} bpm vs {81.4}±{14.9} bpm,P>{0.05}). Conclusion The data indicate that intravenous diltiazem infusion is effective and safe for perioperative patients with hypertension.更多还原