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维生素C在肿瘤防治中角色的再评估

Role of vitamin C in tumor prevention: reappraisal

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【作者】 曹娟郑杰

【Author】 CAO Juan, ZHENG Jie (Molecular Pathology Institute, Department of Pathology and Pathophysiology, School of Basic Medical Science ,Southeast University, Nanjing 210009, China)

【机构】 东南大学基础医学院病理与病理生理学系东南大学基础医学院病理与病理生理学系 江苏南京210009江苏南京210009

【摘要】 维生素C是一种抗氧化剂 ,当它转化成脱氢维生素C的形式则被氧化。维生素C发挥的许多生物学功能与它的氧化还原作用有关。近年来维生素C作为一般的抗氧化剂受到人们的重视 ,作为抗氧化剂它能用于预防和治疗动脉粥样硬化和肿瘤等。值得注意的是在治疗和预防肿瘤过程中 ,由于摄入过多的维生素C也会带来一定的负面影响。弄清这些矛盾的结果 ,对临床合理使用维生素C具有重要意义。

【Abstract】 Vitamin C, also known as ascorbic acid, serves as a reducing agent, which is oxidized during the transfer of reducing equivalents to dihydroascorbic acid. The mechanism of action of vitamin C in many activities is related to its redox system. The role of vitamin C as a general antioxidant has, in recent years, achieved greater attention. In this capacity it is thought to be involved in the prevention and treatment of atherosclerosis and cancer. Again confusion still remains as to the risk of increased intakes of vitamin C in the area of prevention and treatment of cancer. To shed light on these contradictions is very important for reasonably using vitamin C in clinic.

【关键词】 维生素C抗氧化剂肿瘤综述
【Key words】 vitamin Cantioxidantneoplasmsreview
【基金】 教育部留学回国人员科研启动基金 (682 30 0 1 0 0 4 )。
  • 【文献出处】 东南大学学报(医学版) ,Journal of Southeast University , 编辑部邮箱 ,2005年02期
  • 【分类号】R730.5
  • 【被引频次】6
  • 【下载频次】395
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