【摘要】 目的探讨社区新婚夫妻间乙型肝炎病毒传播的干预方法。方法选择社区192对新婚夫妻查体中发现的一方为乙型肝炎病毒携带者,实施有关乙型肝炎病毒夫妻间传播的干预方法:114例乙肝标志物检查(HBV-M)全阴的配偶注射基因工程乙肝疫苗(HBVV),其中18例注射乙肝疫苗前15d先注射乙肝高效价免疫球蛋白(HBIG)2次,200!g/次;其余78例未采用任何预防措施。2年后检测所有被观察者的血清乙肝标志物检查结果。结果114例正规接种基因工程乙肝疫苗的乙型肝炎病毒感染者的配偶的感染率为2.1%,比未接种者的感染率(11.5%)有明显降低,18例同时注射HBIG者之中没有检测到HBV新发感染者的存在。3组乙型肝炎病毒感染率经行乘列2χ检验有显著性差异,P<0.05。结论及时接种基因工程乙肝疫苗和乙肝高效价免疫球蛋白能有效预防乙型肝炎病毒在夫妻间的传播。更多还原

【Abstract】 Objective To explore the intervention methods of hepatitis B virus transmission between the newly-married couples in communities.Methods One hundred and ninety-two couples,with one of every couple carrying hepatitis B virus by physical examinations,were selected in our study to intervene the transmission of virus between spouses.One hundred and fourteen HBV-M negative spouses were treated with injection of HBVV;among them 18 received first injection of HBIG twice,200 ?滋g each time,15 d before injection of HBVV and the rest 78 were controls without any treatment.After 2 years,all of the observed were examined on serum HBV-M.Results The infection rate of the spouses of 114 ones inoculated with HBVV was 2.1%,was significantly lower than that of those(11.5%) without inoculation.But HBV was not detected in the 18 cases inoculated with both HBVV and HBIG.The infection rates of the three groups were significantly different by 2(P<0.05).Conclusion Timely inoculation of HBVV and HBIG can prevent hepatitis B virus from transmission between spouses.更多还原