【摘要】 ①目的探讨早期应用大剂量纳洛酮对急性脑梗死的治疗作用。②方法80例急性脑梗死患者随机分为两组。纳洛酮治疗观察组40例和常规治疗对照组40例,治疗10天后观察患者的颅内压、临床疗效及远期疗效。③结果治疗10天后纳洛酮治疗观察组颅内压增高患者对比对照组明显减少(P<0.05),观察组临床疗效及3个月恢复良好率明显高于对照组(P<0.05)。④结论早期大剂量纳洛酮治疗可使急性脑梗死患者脑水肿减轻,致残率亦少,说明其可促进神经功能恢复。更多还原

【Abstract】 Objective To testify the efficacy of high-dose Naloxone(NIS)in treatment of the acute cerebral infarction(ACI).Methods A ramdmized retrospective clinical trail of 80 patients with ACI(40 cases were treated with NIX and 40 cases were as control)was done.The intracranial pressure(ICP) and clinical effective rate on the tenth day were the index of assessments.Glasgow outcome scale(GOS) in the third month was measured for patient’s prognosis ,Data were statistically analyzed.Result After treatment of NIX 10 days,the patients suffered with high ICP in the NIX groups were less notablly than those in the control group,More patients recovery on the tenth day and low disability rate (P<0.05) after three months in NIX group than in control group(P<0.05).Conclusion This data have confirmed that early applicating of high-dose NIX in treatmont of ACI significantly relieve brain edema,It also improved the recovery and reduce mobidity of the patients with ACI.更多还原