【摘要】 目的测定脑梗死患者血浆中总蛋白S(TPS)、组织型纤溶酶原激活剂(t-PA)、血管性血友病因子(vWF)及纤维连接蛋白(Fn)含量,以探讨这些分子标记物与脑梗死之间的关系。方法均采用ELISA法测定脑梗死患者与正常对照组血浆中TPS、t-PA、vWF和Fn的含量。结果脑梗死患者血浆中TPS和t-PA含量较正常对照组低(P<0.01或0.05),有统计学意义;脑梗死患者血浆中vWF和Fn含量较正常对照组高(P<0.01),有显著差异。结论血浆中总蛋白S、组织型纤溶酶原激活剂、血管性血友病因子及纤维连接蛋白量变化与脑梗死的发病密切相关。更多还原

【Abstract】 Objective To measure the concentration of total proteinS(TPS),tissue plasminogen activator(t-PA),von Willebrand factor(vWF) and fibronection(Fn) in plasma in patients with cerebral infarction and to investigate the relationship between those molecular markers and cerebral infarction.Methods The concentration of TPS,t-PA,vWF and Fn in plasma in patients and normal control group were measured by enzyme-linked immunosorbent assay(ELISA).Results The concentration of TPS and t-PA in plasma in patients were much lower than those normal subjects,P<0.01 or 0.05.It has remarkable significane.Conversely,the level of vWF and Fn were significantly higher in the patients than in the controls(P<0.01).There were marked difference.Conclusion The variety of the concentration of TPS,t-PA vWF and Fn in plasma has a great relationship with the attack of cerebral infarction.更多还原