【摘要】 目的探讨松龄血脉康对高血压病患者血管内皮功能、粥样斑块和左心室肥厚的影响。方法将高血压病患者随机分为松龄血脉康治疗组和吲达帕胺治疗组各36例,另设年龄、性别与之匹配的正常人作为对照组(n=36)。用高分辨超声技术检测各组对象的动脉内皮依赖性舒张功能、颈动脉平均内中膜厚度、颈动脉斑块发生率、Crouse积分及心脏超声。对血脉康组、吲达帕胺组分别在治疗3个月、1年后复查血压和心脏血管超声的上述指标。结果与对照组比较,血脉康组和吲达帕胺组动脉内皮依赖性舒张功能减退,颈动脉内中膜增厚(P<0.05),并出现左室增厚。血脉康组和吲达帕胺组在降低血压及改善内皮依赖舒张功能及逆转左室肥厚方面作用相同(P>0.05),但血脉康在逆转颈动脉内中膜增厚、降低新的粥样斑块发生率方面作用优于吲达帕胺组(P<0.05)。结论松龄血脉康除能有效降低高血压病患者的血压外,还能逆转心脏和大动脉功能和结构异常,延缓动脉粥样硬化进展。更多还原

【Abstract】 Objective To investigate the effect of treatment with song ling xue mai kang on endothelial function and atherosclerosis progression of arteries and left ventricular hypertrophy in hypertensive patients.Methods The patients with essential hypertensive were randomly divided into group A treated with Xuemaikang(n=36)and group B treated with Indapamide(n=36),and another 36 healthy subjects as group C(control group)with matched age and sex.The humeral arterial endothelium-dependent vasodilatation and carotid arterial mean intimal-medial thickness and carotid plagues and left ventriclar structure were measured with high resoiution ultrasongography for each group. For group A and B all above indices and blood pressure were measured again after 3 months,1 year of treatment respectively.Resuits Compared with group C,group A and B had lover humeral arteral endothelium-dependent vasodilatation and thicker carotid mean intimal-medial thickness(P<0.05).there was no difference in reduction of blood pressure and left ventricular hypertophy and improvement of humeral arterial endothelium-dependent vasodilatation between group A and group B,group A had a significantly better effect on normalizing carotid mean intimal-medial thickness and decleasing the incidence of new plagues(P<0.05).Conclusion In addition to reduction of blood pressure,Songling Xuemaikang has an effect on regression of abnormal function and structure of large arteries,which may delay the progression of atherosclerosis,remoding the left ventricular hypertrophy.更多还原