【摘要】 目的　探讨非特异性精神发育迟滞是否为单基因遗传。方法　用分离分析法对所筛查到的 44例非特异性精神发育迟滞儿童家系进行单基因遗传方式分析研究。结果　最大似然法分析可得U×U婚配类型分离比为 2 5 .3 72±0 .1 2 7%、U×A婚配类型分离比为 2 3 .83 9± 0 .73 2 % ,可校正理论子女法可得U×U婚配类型分离比为 2 5 .1 3 %、U×A婚配类型分离比为 3 7.3 7%。结论　分离分析可知U×U婚配类型为常染色体隐性遗传 ,而U×A婚配类型用可校正理论子女法为常染色体隐性遗传、用最大似然法分析则不表现为常染色体隐性遗传。更多还原

【Abstract】 Objective To study whether the pattern of non-special mental retardati on was single gene in heritance. Methods To analyze 44 NSMR pedigrees in segregation analysis methods. Result Segregation ratios were 25.372±0.127% for U×U mating type and 23.839±0.732% for U×A mating type thr ough maximum likelihood estimation method. Segregation ratios were 25.1 3% for U×U mating type and 37.37% for U×A mating type through theoretical children methods. Conclusion U×U mating type shows autosomal recessive inheritance . U×A mating type takes on the possibility of autosomal recessive inheritance i n theoretical children methods.更多还原